IDEXX SDMA testing

What are their kidneys telling you?


Listen closer with IDEXX SDMA

What are their kidneys telling you?


Listen closer with IDEXX SDMA

Detects

diseases of
the kidney sooner1–3

Chronic kidney disease
Acute kidney injury
Pyelonephritis
Upper urinary obstruction
Kidney stones
Glomerulonephritis
Congenital disease

Reflects

other disease processes
affecting the kidneys6

Hyperthyroidism
Vector-borne disease
Systemic hypertension
Cardiorenal syndrome
Lower urinary obstruction
Sepsis
Cancer

Detects

diseases of
the kidney sooner1–3

Chronic kidney disease
Acute kidney injury
Pyelonephritis
Upper urinary obstruction
Kidney stones
Glomerulonephritis
Congenital disease

Reflects

other disease processes
affecting the kidneys7

Hyperthyroidism
Vector-borne disease
Systemic hypertension
Cardiorenal syndrome
Lower urinary obstruction
Sepsis
Cancer

SDMA is a biomarker of kidney function that is  highly correlated with glomerular filtration rate (GFR)1–3

A new standard of care for monitoring kidney function that detects and reflects disease
  • SDMA is a sensitive indicator of kidney function that detects as little as 25% loss of function.1,2
  • SDMA is more reliable than creatinine as an indicator of kidney function because it is not influenced by confounding conditions, such as muscle mass or diet .4,5
  • SDMA is an earlier indicator of progressive kidney function loss, often increasing before other parameters.1–3
  • An increased SDMA may also serve as an indicator of concurrent disease that may have a secondary impact on kidney function.6

 

For deeper insights of into kidney health, for both the sick and well patient, run SDMA every time you run a chemistry panel or you run creatinine and BUN.

Common cases when SDMA is essential

When SDMA is increased and other results are normal

SDMA provides deeper insights than creatinine and BUN alone. 
Look for increased SDMA when other results are normal.


When diagnosing hyperthyroid patients

SDMA diagnoses CKD more in hyperthyroid cats than creatinine and BUN alone because SDMA is not impacted by changes in muscle mass.4,5 Learn more about hyperthyroid cats and the IDEXX SDMA Test. 


When assessing kidney function in puppies and kittens

In puppies, the IDEXX SDMA Test reference interval has been determined to be slightly higher (0–16 μg/dL) than the adult reference interval (0–14 μg/dL). A pediatric reference interval study confirmed that the adult cat reference interval of 0–14 µg/dL is appropriate for use in kittens. 

Assess kidney function of puppies and kittens using SDMA

Deeper insights

Learn more about why SDMA is an essential part of every chemistry panel 

Case study: Coco

Including the Catalyst SDMA Test in Coco’s chemistry panel in his senior wellness visit, lead to an early diagnosis of CKD with concurrent kidney stones. This allowed him to be treated earlier.

Read the case study

Two options: same reliable results

The in-house Catalyst SDMA Test for use with the Catalyst One and Catalyst Dx chemistry analysers
The IDEXX SDMA Test, included with every chemistry panel or as a stand-alone test from IDEXX Reference Laboratories

Note: SDMA is symmetric dimethylarginine.

References

  1. Nabity MB, Lees GE, Boggess M, et al. Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for early detection of chronic kidney disease in dogs. J Vet Intern Med. 2015;29(4):1036–1044.
  2. Hall JA, Yerramilli M, Obare E, Yerramilli M, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. J Vet Intern Med. 2014;28(6):1676–1683.
  3. Hall JA, Yerramilli M, Obare E, Yerramilli M, Almes K, Jewell DE. Serum concentrations of symmetric dimethylarginine and creatinine in dogs with naturally occurring chronic kidney disease. J Vet Intern Med. 2016;30(3):794–802.
  4. Hall JA, Yerramilli M, Obare E, Yerramilli M, Yu S, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides. Vet J. 2014;202(3):588–596.
  5. Hall JA, Yerramilli M, Obare E, Yerramilli M, Melendez LD, Jewell DE. Relationship between lean body mass and serum renal biomarkers in healthy dogs. J Vet Intern Med. 2015;29(3):808–814.
  6. Data on file at IDEXX Laboratories, Inc. Westbrook, Maine USA.
  7. International Renal Interest Society. 2015 IRIS CKD Staging Guidelines. www.iris-kidney.com/guidelines. Accessed May 9, 2018.
  8. Lulich JP, Osborne CA, O'Brien TD, Polzin DJ. Feline renal failure: questions, answers, questions. Compend Contin Educ Pract Vet. 1992;14(2):127–153.
  9. Brown SA. Renal dysfunction in small animals. The Merck Veterinary Manual website. www.merckvetmanual.com/urinary_system/noninfectious_diseases_of_the_urinary_system_in_small_animals/renal_dysfunction_in_small_animals. Updated October 2013. Accessed May 9, 2018.